NWS-630

Lub npe tshuaj:

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide

SMILES Code:

O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3=O)C4=O

InChi Code:

InChI = 1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23) 15-20(3 9-17-9-12-37-13-10-17) 18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1

InChi Key:

ZZWWXIBKLBMSCS-FQEVSTJZSA-N

Lo lus tseem ceeb:

ND-630, ND630, ND 630, GS-0976, GS0976, GS0976, NDI-010976, NDI-010976, NDI 010976, Firsocostat, 1434635-54-7

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

ND-630 inhibits hACC1 (IC50 = 2.1 ± 0.2 nM) thiab hACC2 (IC50 = 6.1 ± 0.8 nM). Inhibition yog thim rov qab thiab tshwj xeeb heev rau ACC. ND-630 inhibits ACC kev ua haujlwm los ntawm kev sib cuam tshuam hauv phosphopeptide-acceptor thiab dimerization site ntawm enzyme los tiv thaiv dimerization. ND-630 inhibits fatty acid synthesis nrog EC50 ntawm 66 nM hauv HepG2 hlwb yam tsis hloov tag nrho cov xov tooj ntawm tes, cellular protein concentration, thiab kev koom ua ke ntawm acetate rau hauv cov roj cholesterol [1].

Hom phiaj: ACC