Vactosertib

Lub npe tshuaj:

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline

SMILES Code:

FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

InChi Code:

InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12- 15) 28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29) )

InChi Key:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Lo lus tseem ceeb:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Vactosertib, tseem hu ua EW-7197 yog ib qho muaj zog ALK5 inhibitor. EW-7197 tau pom muaj zog hauv vivo los tiv thaiv metastatic kev ua haujlwm, qhia tias nws muaj peev xwm siv los ua kev kho mob qog noj ntshav. EW-7197 inhibits TGF-β/Smad signaling. EW-7197 abrogates TGF-β1-induced qog cell migration thiab ntxeem tau. EW-7197 inhibits cancer mis metastasis rau lub ntsws.EW-7197 prolongs lub neej ncua ntawm BALB/c 4T1 nas los ntawm inhibition ntawm EMT. EW-7197 inhibits metastasis thiab txhim kho cov haujlwm ntawm cytotoxic T lymphocytes (CTLs) hauv 4T1 orthotopic grafted nas.

Hom phiaj: ALK