86-21-64556180 ib

RGX-104 HCl

RGX-104 HCl
  • Lub npe:RGX-104 HCl
  • Catalog No.:TIAB SA 1632
  • CAS Nr:.610318-03-1
  • Molecular Luj:632.5452 ib
  • Tshuaj Formula:C34H34Cl2F3NO3
  • Rau kev tshawb fawb tshawb fawb nkaus xwb, tsis yog rau cov neeg mob.

    Product Detail

    Khoom cim npe

    Pob Loj Muaj Nqe (USD)
    100 mg Hauv Tshuag 500
    500 mg Hauv Tshuag 800
    1g Hauv Tshuag 1200
    Ntau qhov ntau thiab tsawg Tau txais Quotes Tau txais Quotes

    Lub npe tshuaj:

    (R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

    SMILES Code:

    O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

    InChi Code:

    InChI = 1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27; h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

    InChi Key:

    LCMIYQOJZLRHTO-GJFSDDNBSA-N

    Lo lus tseem ceeb:

    RGX-104 HCL, RGX-104, RGX 104, RGX 104, 610318-03-1

    Solubility:Soluble hauv DMSO

    Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

    Nqe lus piav qhia:

    RGX-104 yog lub siab X receptor beta agonist nrog lub peev xwm immunomodulating thiab antineoplastic cov dej num. Raws li kev tswj hwm qhov ncauj, RGX-104 xaiv lub hom phiaj thiab khi rau LXRbeta, yog li ua kom LXRbeta-mediated signaling, ua rau kev hloov pauv ntawm qee yam qog nqaij hlav qog thiab txo qis ntawm qee yam qog nqaij hlav qog. Qhov no tshwj xeeb tshaj yog ua kom muaj kev qhia ntawm apolipoprotein E (ApoE), qog nqaij hlav protein, hauv cov qog hlwb thiab qee lub cev tiv thaiv kab mob. Qhov no ua rau lub cev tiv thaiv kab mob hauv lub cev, ua rau txo qis ntawm cov tshuaj tiv thaiv kab mob myeloid-derived suppressor cells (MDSCs), qog hlwb thiab endothelial hlwb hauv cov qog microenvironment. Qhov no thim rov qab kev tiv thaiv kab mob, txhim kho cov qog tiv thaiv kab mob thiab inhibits kev loj hlob ntawm cov qog hlwb.

    Hom phiaj: LXRbeta


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