Bardoxolone methyl hmoov

Lub npe tshuaj:

(4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS) -methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

SMILES Code:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

InChi Code:

InChI = 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) hnub. 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 24+,29+,30-,31-,32+/m1/s1

InChi Key:

WPTTVJLTNAWYAO-OROHISIGSA-N

Lo lus tseem ceeb:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Cov hluavtaws oleanane triterpenoid CDDO (Khoom No. 81035) yog Nrf2 activator uas inhibits proliferation thiab induces sib txawv thiab apoptosis nyob rau hauv ntau yam qog nqaij hlav cancer. C-28 methyl ester ntawm CDDO (CDDO methyl ester) blocks cellular synthesis ntawm inducible nitric oxide synthase (iNOS) thiab inducible COX-2 hauv INF-γ-activated nas macrophages nrog IC50 tus nqi ntawm 0.11 nM. Nws induces apoptosis, induces sib txawv, thiab inhibits inflammatory teb nyob rau hauv ntau yam qog hlwb los ntawm inhibition ntawm IκBα kinase / NF-κB signaling. CDDO methyl ester muaj cov tshuaj tiv thaiv mob ntshav qab zib muaj zog, txo cov kev mob tshwm sim cytokine hauv kev noj zaub mov muaj roj ntau-piv hom 2 mob ntshav qab zib nas thiab hauv Leprdb / db nas thiab ua rau AMP-activated protein kinase thiab LKB1 ua rau cov leeg thiab daim siab.

Hom phiaj: NF-kB