Osimertinib Mesylate

Lub npe tshuaj:

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino phenyl)acrylamide mesylate

SMILES Code:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

InChi Code:

InChI = 1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/ h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

InChi Key:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Lo lus tseem ceeb:

AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Osimertinib, tseem hu ua mereletinib thiab AZD-9291, yog ib tiam thib peb EGFR inhibitor, tau pom cov lus cog tseg hauv kev tshawb fawb ua ntej thiab muab kev cia siab rau cov neeg mob uas muaj mob qog noj ntshav siab uas tau ua rau cov EGFR inhibitors uas twb muaj lawm. AZD9291 yog cov nquag ua haujlwm hauv cov qauv ua ntej thiab tau txais txiaj ntsig zoo hauv cov qauv tsiaj. Nws inhibits ob qho tib si activating thiab resistant EGFR mutations thaum sparing ib txwm daim ntawv ntawm EGFR uas muaj nyob rau hauv ib txwm daim tawv nqaij thiab plab hlwb, li no txo ​​cov kev phiv tshwm sim nrog tam sim no muaj tshuaj. Osimertinib tau pom zoo rau lub Kaum Ib Hlis 2015.

Hom phiaj: EGFR