TX-2761

Lub npe tshuaj:

N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S, 3R, 4R, 5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

SMILES Code:

O=C(NC(C)(C)C(NCCN(C)C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1

InChi Code:

InChI = 1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)3 4-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9, 16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1

InChi Key:

BNPZTRDIESRGTC-IXYVTWBDSA-N

Lo lus tseem ceeb:

LX-2761, LX2761, LX 2761, 1610954-97-6

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

LX2761 yog ib qho chaw ua yeeb yam SGLT1 inhibitor uas muaj zog heev hauv vitro thiab qeeb plab hnyuv nqus dej hauv vivo los txhim kho glycemic tswj. LX2761 muaj hSGLt1 2.2 nM; hSGLT2 2.7 nM and F% =<2. LX2761 yog ib qho muaj zog heev, tshuaj lom neeg ruaj khov, thiab luminally txwv molecule uas ua tiav cov ntaub ntawv pov thawj ntawm lub tswv yim hauv OGTT ntawm koob tshuaj tsawg heev. LX2761 tau tsim kom nyob twj ywm hauv cov hnyuv tom qab qhov ncauj xa mus rau inhibit SGLT1 hauv zos yam tsis muaj kev cuam tshuam rau SGLT1/2 mechanism hauv lub raum.

Hom phiaj: SGLT1