PEB-1895344

Lub npe tshuaj:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

SMILES Code:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

InChi Code:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25) ;1H/t13-;/m1./s1

InChi Key:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Lo lus tseem ceeb:

1876467-74-1; CAS: 1876467-74-1; CAS: 1876467-74-1; BAY-1895344, BAY 1895344, BAY 1895344

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

BAY-1895344 yog ib qho kev xaiv ATR (ataxia-telangiectasia thiab Rad3 ntsig txog protein) inhibitor uas inhibits proliferation ntawm ib tug dav spectrum ntawm tib neeg qog cell kab (median IC50 = 78 nM). BAY-1895344 yog tsim los rau kev kho mob ntawm cov neeg mob uas muaj cov qog nqaij hlav thiab lymphomas siab heev, thiab nws tab tom tab tom mus rau theem I kev sim tshuaj ntsuam xyuas kev nyab xeeb thiab kev zam rau cov neeg mob qog noj ntshav.

Hom phiaj: ATR