SWB 2256098 Stb

Lub npe tshuaj:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

SMILES Code:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

InChi Code:

InChI = 1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22) -18) 23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23) , 24)

InChi Key:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Lo lus tseem ceeb:

GSK 2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

GSK2256098, tseem hu ua GTPL7939, yog ib qho focal adhesion kinase-1 (FAK) inhibitor uas muaj peev xwm antiangiogenic thiab antineoplastic cov dej num. FAK inhibitor GSK2256098 inhibits FAK, uas tuaj yeem tiv thaiv kev sib koom ua ke ntawm kev sib koom ua ke ntawm ntau txoj hauv kev hauv qab cov teeb liab, suav nrog ERK, JNK / MAPK thiab PI3K / Akt, yog li inhibiting qog cell migration, proliferation thiab ciaj sia taus, thiab qog angiogenesis. Lub tyrosine kinase FAK feem ntau yog qhib los ntawm kev khi rau integrins nyob rau hauv lub extracellular matrix (ECM) tab sis tej zaum yuav upregulated thiab constitutively activated nyob rau hauv ntau hom qog cell.

Hom phiaj: FAK