Batefenterol

Lub npe tshuaj:

(R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl))amino)) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"

SMILES Code:

O=C(OC1CCN(CCC(NC2=CC(OC))=CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

InChi Code:

InChI = 1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29) 12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H, 15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

InChi Key:

URWYQGVSPQJGGB-DHUJRADRSA-N

Lo lus tseem ceeb:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Batefenterol yog ib tug muscarinic antagonist thiab β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, thiab 3.7 nM, rau hM2, hM3, thiab hβ2-AR, raws li nyob rau hauv ib tug radioligand binding assay). Batefenterol nthuav tawm muaj zog hβ2-AR agonist kev ua haujlwm (EC50 = 0.29 nM) nrog 440- thiab 320-fold ua haujlwm xaiv tshaj hβ1- thiab hβ3-ARs, feem. cov ntaub so ntswg thiab inhibits bronchoconstrictor teb nyob rau hauv ib tug guinea npua bronchoprotection assay (ED50 = 6.4 µg / mL). Cov qauv uas muaj batefenterol yog nyob rau hauv kev sim tshuaj kho mob ntev obstructive pulmonary disease (COPD).

Hom phiaj: β2-adrenoceptor