PRT-060318; PRT318; P142–76

Inoa Kimia:

2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide

SMILES Code:

O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

Code InChi:

InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1

Ki InChi:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

huaʻōlelo:

PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO ka PRT060318 he mea hoʻopaneʻe ikaika a koho i ka spleen tyrosine kinase (Syk; IC50 = 4 nM) . 270 kinase. PRT060318 inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM) in vitro and prevent thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia. Hoʻoulu ia i ka maʻi leukemia lymphocytic maʻi (CLL) B cell apoptosis a keʻakeʻa i ka huna ʻana o nā chemokines CCL3, CCL4, a me CXCL13.3 PRT060318 hoʻi i ka CLL B cell chemotaxis a me pseudoemperipolesis.

Pahuhopu: Syk