BAY 61-3606 2HCl

Inoa Kimia:

2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

SMILES Code:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

Code InChi:

InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) ;2*1H

Ki InChi:

SPMFEULFGGPQLN-UHFFFAOYSA-N

huaʻōlelo:

BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO BAY 61-3606 he mea ikaika (Ki = 7.5 nM) a me ka mea hoʻopaneʻe koho o Syk kinase. ʻO BAY 61-3606 i kāohi ʻaʻole i ka degranulation wale nō (nā waiwai IC50 ma waena o 5 a me 46 nM) akā pū kekahi lipid mediator a me cytokine synthesis i loko o nā mast cell. ʻO ka BAY 61-3606 ka mea maikaʻi loa i nā basophils i loaʻa mai nā kānaka olakino olakino (IC50 = 10 nM) a me he mea lā he ikaika loa i nā basophils i loaʻa mai nā kumuhana atopic (high serum IgE) (IC50 = 8.1 nM). ʻO ka hoʻoulu ʻana o ka mea hoʻolale pūnaewele B a me nā mea loaʻa no ka ʻāpana Fc o ka hōʻailona IgG i nā eosinophils a me nā monocytes i hoʻopaʻa ikaika ʻia e BAY 61-3606.

Pahuhopu: Syk