TH-302; Evofosfamide

Inoa Kimia:

N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

SMILES Code:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

Code InChi:

InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

Ki InChi:

UGJWRPJDTDGERK-UHFFFAOYSA-N

Hua'ōlelo:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO Evofosfamide, i ʻike ʻia ʻo TH-302, he prodrug hypoxia-activated i loaʻa i kahi conjugate 2-nitroimidazole phosphoramidate me ka hana antineoplastic. ʻO ka 2-nitroimidazole moiety o hypoxia-activated prodrug TH-302 e hana ma ke ʻano he hypoxic trigger, e hoʻokuʻu ana i ka DNA-alkylating dibromo isophosphoramide mustard moiety i loko o nā ʻāpana hypoxic o nā ʻōpū. Hiki ke mālama ʻia nā ʻiʻo normoxic ma muli o ka hana hypoxia-specific o kēia mea hana, hiki ke hōʻemi i ka ʻona ʻōnaehana. E nānā no nā hoʻokolohua lapaʻau ikaika a i ʻole nā ​​hoʻokolohua lapaʻau pani ʻia me ka hoʻohana ʻana i kēia mea hana. (NCI).

Pahu: DNA Alkylating Agent