AZD7507

Inoa Kimia:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

SMILES Code:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Code InChi:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32)(H,26,27)

Ki InChi:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Hua'ōlelo:

AZD7507; AZD-7507; AZD 7507

Hiki ke hoʻoheheʻe:DMSO

Waihona: 

wehewehe:

ʻO AZD7507 kahi mea hoʻopale CSF-1R ikaika a koho (32 nM cell activity), ua manaʻo ʻia ʻo AZD7507 he pūhui hoʻohiki i ka mālama ʻana i ka mana makemake a me nā waiwai pharmacokinetic waha o AZ683. Eia kekahi, ma kahi haʻawina telemetry i nā ʻīlio i hāʻawi ʻia i hoʻokahi pānaʻi waha, ʻaʻohe mea ʻona o ka maʻi cardiovascular, ʻaʻohe piʻi o ka troponin e pili ana i ka mālama ʻana, ʻaʻohe hoʻololi i ka ECG.

Pahuhopu: CSF-1R