BAY-299

Inoa Kimia:

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H)-dione

SMILES Code:

OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

Code InChi:

InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11H2,1-3H3

Ki InChi:

OFWWWKWUCDUISA-UHFFFAOYSA-N

Hua'ōlelo:

BAY-299, BAY 299, BAY299, 2080306-23-4

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO BAY-299 kahi mea hoʻopaneʻe ikaika a koho i ka bromodomain a me ka PHD finger-containing (BRPF) ʻohana protein BRD1 (IC50 = 6 nM), i ʻike ʻia ʻo BRPF2, a me ka bromodomain ʻelua o ka transcription initiation factor TFIID subunits 1 (TAF1; IC50). = 13 nM).1 BAY-299 he >30-palua koho ma luna o BRPF1, BRPF3, ʻO BRD9, a me ATAD2 a he> 300-fold koho ma luna o BRD4.

Kuhikuhi: BRPF