BI-3406

Inoa Kimia:

N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amina

SMILES Code:

C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2

Code InChi:

InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1

Ki InChi:

XVFDNRYZXDTHHT-PXAZEXFGSA-N

huaʻōlelo:

BI-3406; BI 3406; BI3406

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO BI-3406 ka SOS1 Potent & Selective :: KRAS Inhibitor (IC50=5 nM), e wehe ana i kahi ala hou no ka mālama ʻana i nā maʻi maʻi KRAS-Driven. Hoʻopili koho ʻo BI 3406 iā SOS1 a pale i ka pilina me KRAS, me ka ʻole o ka hoʻololi ʻana o KRAS. ʻO BI 3406 ka mea e hoʻemi ai i ka RAS GTP a me ka pERK a keʻakeʻa i ka ulu ʻana o ke kelepona o nā laina kelepona ʻokoʻa KRAS, e lawe ana i ka hapa nui o nā hoʻololi KRAS maʻamau (ie G12D, G12V, G13D a me nā mea ʻē aʻe). ʻO BI 3406, i ka wā e lawelawe waha ʻia ai i nā ʻiole e lawe ana i ka ʻiole, hoʻoulu i kahi hopena static e pili ana i ka maʻi maʻi hiki ke hoʻololi ʻia i regressions ke hui pū ʻia me MEK1 inhibition.

Pahuhopu: SOS1