BMS-986165

Inoa Kimia:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 -carboxamide

SMILES Code:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Code InChi:

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23 ,24,25,29)/i1D3

Ki InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

huaʻōlelo:

1609392-27-9；CAS:1609392-27-9；CAS:1609392-27-9；BMS-986165; BMS 986165; BMS986165; ʻO Deucravacitinib

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:Māloʻo, ʻeleʻele a ma 0 - 4 C no ka wā pōkole (nā lā i nā pule) a i ʻole -20 C no ka wā lōʻihi (mai nā mahina a hiki i nā makahiki).

wehewehe:

ʻO BMS-986165 kahi mea hōʻemi Allosteric kiʻekiʻe a koho ʻia o TYK2. ʻO BMS-986165 Blocks Il-12, IL-23 a me ke ʻano I Interferon Signaling a hāʻawi i ka mana ikaika i nā ʻano preclinical o ka maʻi inflammatory bowel. Hoʻopaʻa ikaika ʻo MS-986165 i ka Tyk2 pseudokinase domain (Ki = 0.02 nM), a koho nui loa i kahi panel o 265 kinases a me pseudokinases. Hoʻopaʻa ikaika ka hui i ka IL-23-, IL-12-, a me Type I interferon-driven cellular signaling a me nā pane transcriptional (IC50 range 2-14 nM).

Pahuhopu: TYK2