SOS1

CAT #	Inoa Huahana	wehewehe
CPD10000	BI-3406	ʻO BI-3406 ka SOS1 Potent & Selective :: KRAS Inhibitor (IC50=5 nM), e wehe ana i kahi ala hou no ka mālama ʻana i nā maʻi maʻi KRAS-Driven. Hoʻopili koho ʻo BI 3406 iā SOS1 a pale i ka pilina me KRAS, me ka ʻole o ka hoʻololi ʻana o KRAS. ʻO BI 3406 ka mea e hoʻemi ai i ka RAS GTP a me ka pERK a keʻakeʻa i ka ulu ʻana o ke kelepona o nā laina kelepona ʻokoʻa KRAS, e lawe ana i ka hapa nui o nā hoʻololi KRAS maʻamau (ie G12D, G12V, G13D a me nā mea ʻē aʻe). ʻO BI 3406, i ka wā e lawelawe waha ʻia ai i nā ʻiole e lawe ana i ka ʻiole, hoʻoulu i kahi hopena static e pili ana i ka maʻi maʻi hiki ke hoʻololi ʻia i regressions ke hui pū ʻia me MEK1 inhibition.
CPD2807	BAY-293	ʻO BAY-293 kahi mea hoʻopaneʻe SOS1 ikaika e ālai i ka hoʻoulu ʻana o RAS ma o ka hoʻopau ʻana i ka pilina RAS-SOS1. BAY-293) koho i ka pilina KRAS-SOS1 me kahi IC50 o 21 nM a he noiʻi kemika waiwai no nā noiʻi e hiki mai ana.