AZD8186

Inoa Kimia:

(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES Code:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Code InChi:

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

Ki InChi:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Hua'ōlelo:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO AZD8186 a me ka mea hoʻopaneʻe o ka beta isoform o phosphoinositide-3 kinase (PI3K), me ka hana antineoplastic. Ma luna o ka hoʻoponopono ʻana, PI3Kbeta inhibitor AZD8186 koho koho i ka hana o PI3Kbeta ma ke ala hōʻailona PI3K/Akt/mTOR, a hiki ke hopena i ka emi ʻana o ka hoʻonui ʻana o ka cell tumor. Hoʻokomo pū ia i ka make cell i loko o PI3K-expressing cancer cells. Ma ke kuhikuhi pono ʻana i ka papa I PI3K beta, ʻoi aku ka maikaʻi o kēia mea hana a ʻoi aku ka ʻawaʻawa ma mua o ka pan PI3K inhibitors. Hoʻopili pinepine ʻia ka hōʻailona PI3K-mediated i loko o nā keʻena maʻi maʻi a kōkua i ka hoʻonui ʻana i ka ulu ʻana o ka cell tumo, ola, a me ke kūpaʻa ʻana i nā ʻano ʻano antineoplastic. Aia ʻo AZD8186 ma lalo o nā hoʻokolohua lapaʻau Phase I.

Pahuhopu: PI3K