DEL-22379

Inoa Kimia:

(Z)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide

SMILES Code:

O=C(NC1=CC2=C(NC(/C2=C/C3=CNC4=C3C=C(OC)C=C4)=O)C=C1)CCN5CCCCC5

Code InChi:

InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21) 29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2, 1H3,(H,28,31)(H,29,32)/b22-13+

Ki InChi:

INQUULPXCZAKMS-LPYMAVHISA-N

Hua'ōlelo:

DEL-22379, DEL22379, DEL 22379, 181223-80-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO DEL-22379 kahi mea hoʻopaneʻe ERK Dimerization ikaika a koho. Kāohi ʻo DEL-22379 i ka ERK Dimerization me ka ʻole e pili ana i ka phosphorylation ERK, pale i ka tumorigenesis i alakaʻi ʻia e RAS-ERK ala oncogenes. Ma kahi kokoke i 50% o nā maʻi maʻi kanaka e hōʻike i ka hōʻailona RAS-ERK i hoʻoponopono ʻole ʻia; ʻO ke kaohi ʻana he hoʻolālā kūpono no ka hana antineoplastic.

Kuhikuhi: ERK