Quizartinib; AC-010220; AC-220

Inoa Kimia:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

SMILES Code:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

Code InChi:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

Ki InChi:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Hua'ōlelo:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO Quizartinib kahi mea pale o FMS pili tyrosine kinase 3 (FLT3; Kd = 1.6 nM) a hōʻike i ke koho kiʻekiʻe no FLT3 ke hoʻāʻo ʻia e kūʻē i kahi panel o 227 kinases hou. Hoʻopaʻa ia i ka hoʻonui ʻana o ka laina cell leukemia kanaka MV4-11, kahi i hoʻopaʻa ʻia i ka homozygous FLT3-ITD mutation, me kahi waiwai IC50 o 0.56 nM.1 Ma 1 mg / kg / lā, ua hōʻike ʻia ʻo quizartinib e hoʻolōʻihi i ke ola ʻana i ka ʻiole. kumu hoʻohālike o FLT3-ITD acute myeloid leukemia a e hoʻopau i nā maʻi koko i loko o kahi kumu hoʻohālike xenograft ʻiole pili FLT3 ma 10 mg/kg.

Pahuhopu: FLT3