Saukewa: NTN21277

Sunan Sinadari:

(2S,4R)-1-((S)-2-(3-(2-((5-(4-((3-chloro-4-fluorophenyl))))-7-methoxyquinazolin-6-yl)) oxy) pentyl) ethoxy) propanamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide

Lambar SMILES:

O= C =O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Lambar InChi:

InChi=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1

InChi Key:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Mabuɗin kalma:

Gefitinib na tushen PROTAC 3; NTN21277; NTN-21277; Farashin NTN21277

Solubility: 

Ajiya: 

Bayani:

NTN21277, wanda kuma aka sani da Gefitinib na tushen PROTAC 3 shine PROTAC mai daukar ma'aikata na VHL wanda ke haifar da lalatawar EGFR da EGFR mutants tare da DC50 na 11.7 nM da 22.3 nM don tantanin halitta HCC827 (Exon 19 del) da tantanin halitta H3258R (L).

Saukewa: EGFR