Saukewa: AZD-3409

Sunan Sinadari:

(S) -isopropyl 2- (2- (4-fluorophenethyl) -5- (((2S,4S) -4- (nicotinoylthio) pyrrolidin-2-yl) methyl) amino) benzamido) -4- (methylthio) butanoate

Lambar SMILES:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Lambar InChi:

InChi=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26 (35)12-8-23)37-20-28-17-29 (21-38-28) 45-34 (42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3, (H,39,40)/t28-,29-,31-/m0/s1

InChi Key:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Mabuɗin kalma:

AZD3409; AZD-3409; Farashin 3409

Solubility: 

Ajiya: 

Bayani:

AZD-3409 shine mai hanawa prenyl transferase mai ƙarfi. AZD-3409 ya nuna ƙarfi fiye da lonafarnib. Ma'anar IC (50) don cytotoxicity na AZD3409 shine 510 a cikin kwayoyin MEF, 10,600 a cikin kwayoyin A549 da 6,170 a cikin kwayoyin MCF7, bi da bi. A cikin waɗannan sel, IC (50) don aikin FTase na AZD3409 ya kasance daga 3.0 zuwa 14.2 nM da na lonafarnib daga 0.26 zuwa 31.3 nM. AZD3409 yana hana farnesylation zuwa mafi girma fiye da geranylgeranylation. Dukansu hana farnesylation da geranylgeranylation ba za a iya danganta su da aikin antiproliferative na miyagun ƙwayoyi ba. AZD3409 na iya yin aiki a cikin ciwon nono mai jure gefitinib.

Manufa: prenyl transferase inhibitor