EAI-045

Sunan Sinadari:

2- (5-fluoro-2-hydroxyphenyl) -2- (3-oxo-1H-isoindol-2-yl) - N- (1,3-thiazol-2-yl) acetamide

Lambar SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Lambar InChi:

InChi=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

InChi Key:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Mabuɗin kalma:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

EAI045 ita ce mai ƙarfi da zaɓin mai hana EGFR. EAI045 ya yi niyyar zaɓaɓɓun maye gurbi na EGFR masu jure magunguna amma yana hana mai karɓar nau'in daji. EAI045 yana hana L858R/T790M-mutant EGFR tare da ƙarancin ikon nanomolar a cikin gwajin sinadarai.

Saukewa: EGFR