JBJ-04-125-02 R-isomer
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
Sunan Sinadari:
(R) -2- (5-fluoro-2-hydroxyphenyl) -2- (1-oxo-6- (4- (piperazin-1-yl) phenyl) isoindolin-2-yl) -N- (thiazol-2) -yl) acetamide
Lambar SMILES:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Lambar InChi:
InChi=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19 (15-23 (20)28 (35)38)18-3-6-22 (7-4-18) 34-12-9-31-10-13-34/h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
Mabuɗin kalma:
Solubility:
Ajiya:
Bayani:
JBJ-04-125-02 mutant-zaɓi EGFR allosteric inhibitor tare da yuwuwar aikin anticancer. A matsayin wakili guda ɗaya, zai iya hana yaduwar kwayar halitta da EGFRL858R/T790M/C797S sigina a cikin vitro da in vivo. Haɗuwa da osimertinib da JBJ-04-125-02 yana haifar da karuwa a cikin apoptosis, ingantaccen hana haɓakar salon salula, da haɓaka haɓakawa a cikin vitro da in vivo idan aka kwatanta da ko dai wakili ɗaya kaɗai.
Saukewa: EGFR
