Sildenafil citrate

Ainm Ceimigeach:

5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- 7-aon 2-hydroxypropane-1,2,3-tricarboxylate

Còd SMILES:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O) )C(CC(=O)O)(C(=O)O)O"

Còd InChi:

InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10- 26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2, 1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

iuchair InChi:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Facal-luirg:

Sildenafil Citrate ；UK 92480-10；UK-92,480-10； Ath-bheothachadh； VIAGRA； 171599-83-0； CAS: 171599-83-0； CAS: 171599-83-0

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Is e cruth citrate de Sildenafil a th’ ann an sildenafil, citrate. Tha Sildenafil na neach-dìon roghnach de PDE5 (seòrsa 5 cGMP phosphodiesterase) a bhios a’ cuairteachadh uisgeachadh guanosine monophosphate 3’,5’-cyclic (cGMP). Mar neach-dìon PDE5, chaidh aithris gu bheil Sildenafil ag àrdachadh neuro-, synapto- agus angiogenesis ann am modalan radan de stròc agus thathar ag aithris cuideachd gu bheil e na vasodilator tlàth. Thathas air sealltainn gu bheil Sildenafil cuideachd a’ cur casg air cruthachadh ulceration caolan beag air a bhrosnachadh le indomethacin tro inneal a tha an urra ri NO / cGMP.

Targaid: PDE5