ND-630

Ainm Ceimigeach:

(R) -2-(1-(2-(2-methoxyphenyl))-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide

Còd SMILES:

O=C(N)C(C)(C)N(C(N(C[C@H)(C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=) CO5)S3)=O)C4=O

Còd InChi:

InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23) 15-20 (39-17-9-12-37-13-10-17) 18-7-5-6-8-19 (18) 36-4 / h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1

iuchair InChi:

ZZWWXIBKLBMSCS-FQEVSTJZSA-N

Facal-luirg:

ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Tha ND-630 a’ bacadh HACC1 (IC50 = 2.1 ± 0.2 nM) agus HACC2 (IC50 = 6.1 ± 0.8 nM). Tha casg air a thionndadh air ais agus gu math sònraichte airson ACC. Tha ND-630 a 'bacadh gnìomhachd ACC le bhith ag eadar-obrachadh taobh a-staigh làrach fosphopeptide-acceptor agus dimerization an enzyme gus casg a chur air lùghdachadh. Tha ND-630 a’ cur bacadh air synthesis searbhag geir le EC50 de 66 nM ann an ceallan HepG2 gun a bhith ag atharrachadh an àireamh cealla iomlan, dùmhlachd pròtain ceallach, agus a’ toirt a-steach acetate a-steach do cholesterol [1].

Targaid: ACC