Luxdegalutamide; ARV-766

Ainm Ceimigeach:

4-(4-((1-(4-(((1r,3r)-3-(4-cyano-3-methoxyphenoxy))-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperidin-4- yl)methyl) piperazin-1-il)-N-((S)-2,6-dioxopiperidin-3-il)-2-fluorobenzamide

Còd SMILES:

CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F))=C(C(N[C@H]6C(=O)NC(=O)) CC6)=O)C=C5)CC4)CC3)C=C2)=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

Còd InChi:

InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50- 39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32- 11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36, 42-43H, 14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1

iuchair InChi:

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

Facal-luirg:

2750830-09-0 ； CAS: 2750830-09-0 ； CAS: 2750830-09-0 ；ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

Solubility: 

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean).

Tuairisgeul:

Tha Luxdegalutamide (ARV-766) na inneal èifeachdach beòil hydrolysis pròtain cuimsichte chimeric (PROTAC) ag amas air receptor androgen (AR), a dh'fhaodas mutants co-cheangailte ri strì AR a lughdachadh.

Targaid: AR