LOXO-305;LY 3527727; Pirtobrutinib

Ainm Ceimigeach:

(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-il)-1H-pyrazole-4- carboxamide

Còd SMILES:

O=C(C1=C(N)N([C@H)(C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F))=CC=C3OC) )=O)C=C2)N

Còd InChi:

InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6- 13) 10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32 (H,29,33)/t11-/m0/s1

iuchair InChi:

FWZAWAUZXYCBKZ-NSHDSACASA-N

Facal-luirg:

2101700-15-4 CAS:2101700-15-4

Solubility: 

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean).

Tuairisgeul:

Tha Pirtobrutinib (LOXO-305) na neach-dìon BTK an ath ghinealach a tha gu math roghnach agus neo-chovalent a dh’ fhaodadh casg a chuir air grunn mhùthaidhean ionadachaidh BTK C481.

Targaid: BTK