Zidesamtinib; NVL-520

Gemyske namme:

(6R)-22-etyl-54-fluor-42,6-dimethyl-22H,42H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptafan-16-amine

SMILES Koade:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC )C

InChi Koade:

InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25) )/t12-/m1/s1

InChi Key:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Keyword:

2739829-00-4；CAS：2739829-00-4；CAS:2739829-00-4；Zidesamtinib; NVL-520; NVL520; NVL 520

Oplosberens: 

Opslach:Droog, tsjuster en by 0 - 4 C foar koarte termyn (dagen oant wiken) of -20 C foar lange termyn (moannen oant jierren).

Beskriuwing:

Zidesamtinib (NVL-520) is in effektive, selektive, oraal aktive, en bloed-brain barriêre permeable ROS1-fúzje en ferset mutaasje-ynhibitor.

Doel: ROS1