| KAT # | Produkt Namme | Beskriuwing |
| CPD3611 | SB-204990 | SB-204990 is de prodrug fan 'e potente ATP-citrate-lyase-ynhibitor SB-201076. SB-204990, doe't mûnling oan ratten administraasje waard, waard opnommen yn 'e systemyske sirkulaasje, farmakologysk relevante konsintraasjes fan SB-201076 waarden weromfûn yn' e lever. SB-204990 (25 mg / kg per dei) ferlege ek plasma-cholesterolnivo's (mei maksimaal 23%) en triglyceridenivo's (mei oant 38%) yn 'e hûn, by foarkar ôfnimmend lipoprotein mei lege tichtheid yn ferliking mei hege tichtheid lipoprotein cholesterol nivo's. SB-204990 is in wichtich enzyme by it kontrolearjen fan substraatoanfier foar lipidesynteze de novo en in potinsjele enzymedoel foar hypolipidemyske yntervinsje. |
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