LOXO-305;LY 3527727;Pirtobrutinib

Gemyske namme:

(S)-5-amino-3-(4-((5-fluor-2-methoxybenzamido)methyl)fenyl)-1-(1,1,1-trifluorpropan-2-yl)-1H-pyrazol-4- karboksamide

SMILES Koade:

O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3OC )=O)C=C2)N

InChi Koade:

InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6- 13)10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32) )(H,29,33)/t11-/m0/s1

InChi Key:

FWZAWAUZXYCBKZ-NSHDSACASA-N

Keyword:

2101700-15-4; CAS: 2101700-15-4; CAS: 2101700-15-4; LOXO-305; LOXO 305; LOXO 305; LY 3527727; 727727; 727727; 727727; 727727

Oplosberens: 

Opslach:Droog, tsjuster en by 0 - 4 C foar koarte termyn (dagen oant wiken) of -20 C foar lange termyn (moannen oant jierren).

Beskriuwing:

Pirtobrutinib (LOXO-305) is in heul selektive en net-kovalente BTK-ynhibitor fan folgjende generaasje dy't ferskate BTK C481-substitúsjonele mutaasjes kin remme.

Doel: BTK