ARS-1323

የኬሚካል ስም

1- (4- (6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl) prop-2-en-1-one

የፈገግታ ኮድ፡-

O=C(C=C)N1CCN(C2=NC=NC3=C2C=C(Cl)C(C4=C(O)C=CC=C4F)=C3F)CC1

የኢንቺ ኮድ

InChi=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25- 11-26-21)18-14(23)4-3-5-15(18)29/ሰ2-5፣10-11፣29H፣1፣6-9H2

የኢንቺ ቁልፍ፡

ZRPZPNYZFSJUPA-UHFFFAOYSA-N

ቁልፍ ቃል፡

ARS1323፣ARS 1323፣ARS-1323፣ 1698024-73-5

መሟሟት;በዲኤምኤስኦ ውስጥ የሚሟሟ

ማከማቻ፡0 - 4°C ለአጭር ጊዜ (ከቀናት እስከ ሳምንታት)፣ ወይም -20°C ለረጅም ጊዜ (ወራት)

መግለጫ፡-

ARS-1323 ከፓተንት WO 2015054572 A1 የወጣ የ mutant K-ras G12C ልብ ወለድ አጋቾች ነው። IC50 እና ዒላማ፡ K-ራስ G12C

ዒላማ፡ KRAS (K-ራስ G12C)