I-AZD8186

Igama Lekhemikhali:

(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

Ikhodi ye-SMILES:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Ikhodi ye-InChi:

I-InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

I-InChi Key:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Igama elingukhiye:

I-AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-AZD8186 iyisivimbeli se-beta isoform ye-phosphoinositide-3 kinase (PI3K), enekhono lomsebenzi we-antineoplastic. Lapho ilawulwa, i-PI3Kbeta inhibitor AZD8186 ivimbela ngokukhetha umsebenzi we-PI3Kbeta kumzila wokusayinda we-PI3K/Akt/mTOR, okungase kuphumele ekwehleni kokusabalala kweseli yesimila. Iphinde ibangele ukufa kwamaseli kumaseli omdlavuza aveza i-PI3K. Ngokuqondisa ngokukhethekile i-beta yekilasi I-PI3K, le ejenti ingase isebenze kahle futhi ingabi nobuthi obuncane kune-pan PI3K inhibitors. Ukusayinwa kwe-PI3K-mediated kuvame ukulawulwa kumaseli omdlavuza futhi kunomthelela ekwandiseni ukukhula kwamaseli e-tumor, ukusinda, kanye nokumelana nesimila kuma-antineoplastic agent. I-AZD8186 okwamanje ingaphansi kwezivivinyo zomtholampilo zeSigaba I.

Ithagethi: PI3K