I-STING agonist-4
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
Igama Lekhemikhali:
1,1'-(butane-1,4-diyl) bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)
Ikhodi ye-SMILES:
O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC) (C)=NN6CC)=O)=NC2=C1)N
Ikhodi ye-InChi:
I-InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23-17-21(29(35)47)9-11- 25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)48)18-24(26)38-34(44)40-32(50) 28-16-20(4)42-46(28)6-2/h9-12,15-18H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36, 48)(H,37,39,49)(H,38,40,50)
I-InChi Key:
I-ICZSAXDKFXTSGL-UHFFFAOYSA-N
Igama elingukhiye:
Ukunyibilika:
Isitoreji:
Incazelo:
I-STING agonist-4 iyisikhuthazi se-Interferon Genes (STING) receptor agonist ene-apparent inhibitory constant (IC50) yama-20 nM. I-STING agonist-4 iyinhlanganisela esekelwe ku-symmetry ehlobene ne-amidobenzimidazole (ABZI) ukuze idale ama-ABZI axhunyiwe (diABZIs) abophezelekile ku-STING kanye nomsebenzi weselula.
Ithagethi: STING