I-STING agonist-3

Igama Lekhemikhali:

(E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)kodwa-2- en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-5-carboxamide

Ikhodi ye-SMILES:

O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCO)C3=C1

Ikhodi ye-InChi:

I-InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(32(38)51)10-11- 27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55-15-9-14-50)41- 37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20,50H,5-6,9,12- 15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8-7+

I-InChi Key:

VHCDRDBBENBVEK-BQYQJAHWSA-N

Igama elingukhiye:

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-STING agonist-3, ekhishwe ku-patent WO2017175147A1 (isibonelo 10), iyi-agonist ekhethiwe futhi engeyona i-nucleotide ye-molecule encane ye-STING ene-pEC50 ne-pIC50 ye-7.5 kanye ne-9.5, ngokulandelanayo. I-STING agonist-3 inomphumela oqinile wokulwa nesimila namandla amakhulu okuthuthukisa ukwelashwa komdlavuza

Ithagethi: STING