PCO371

PCO371
  • Igama:PCO371
  • Inombolo yekhathalogi:CPD2050
  • Inombolo ye-CAS:1613373-33-3
  • Isisindo se-Molecular:635.20
  • I-Chemical Formula:I-C29H32F3N5O6S
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)

    Igama Lekhemikhali:

    1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro[4.5]dec-1-zu-8-yl )sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

    Ikhodi ye-SMILES:

    O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

    Ikhodi ye-InChi:

    I-InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

    I-InChi Key:

    LTZJFVOUPUFOHX-UHFFFAOYSA-N

    Igama elingukhiye:

    I-PCO371; I-PCO-371; I-PCO 371

    Ukunyibilika: 

    Isitoreji: 

    Incazelo:

    I-PCO371 iyi-agonist enamandla futhi ekhethiwe ye-PTHR1 yokwelashwa kwe-hypoparathyroidism. Ukuphathwa komlomo kwe-PCO371 kumagundane e-osteopenic kubangela ukwanda okuphawulekayo kokuguqulwa kwamathambo ngokunyuka okulinganiselwe kwesisindo samathambo. Kumagundane e-hypocalcemic, i-PCO371 ibuyisela amazinga e-serum calcium ngaphandle kokwandisa i-calcium yomchamo, futhi ibe nemiphumela enamandla futhi ehlala isikhathi eside kunemijovo ye-PTH.

    Ithagethi: PTHR1


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