SJ-01

Igama Lekhemikhali:

(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Ikhodi ye-SMILES:

O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O

Ikhodi ye-InChi:

I-InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6- 15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+

I-InChi Key:

VABYUUZNAVQNPG-BQYQJAHWSA-N

Igama elingukhiye:

20069-09-4;CAS:20069-09-4;CAS:20069-09-4;Piperlongumine; I-Piplatine.

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:Eyomile, emnyama futhi ku-0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

Incazelo:

I-Piperlongumine, eyaziwa nangokuthi i-Piplartine, i-alkaloid/amide esebenzayo ngokwebhayoloji evela kupelepele, njengokusuka kupelepele omude (Piper longum L. - Piperaceae). Upelepele omude ungenye yezinto ezisetshenziswa kakhulu emithini ye-Ayurvedic, esetshenziselwa ukwelapha izifo eziningi, kufaka phakathi izimila. Imisebenzi ebikiwe ye-pharmacological ye-piplatine ihlanganisa i-cytotoxic, i-genotoxic, i-antitumor, i-antiangiogenic, i-antimetastatic, i-antiplatelet aggregation, i-antinociceptive, i-anxiolytic, i-anti-depressant, i-anti-atherosclerotic, i-antidiabetic, i-antibacterial, i-antifungal, i-leishmanicidal, i-trypanocistomidal, kanye nemisebenzi ye-schistomidal. Phakathi kwemiphumela eminingi yemithi ye-piplatine, impahla yayo ye-anticancer iyona ethembisa kakhulu.

Ithagethi: I-Piperlongumine iyi-alkaloid evimbela ukuguqulwa kwe-myofibroblasts ngokuvimbela indlela yokubonisa i-erk1/2