I-NST-628

Igama Lekhemikhali:

3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(3-fluoropyridin-2-yl)oxy-4-methylchromen-2-one

Ikhodi ye-SMILES:

FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4= C2)N=CC=C1

Ikhodi ye-InChi:

I-InChI=1S/C22H18F2N4O5S/c1-12-15-6-5-14(32-21-17(23)4-3-8-27-21)11-18(15)33-22(29)16( 12)10-13-7-9-26-20(19(13)24)28-34(30,31)25-2/h3-9,11,25H,10H2,1-2H3,(H,26 , 28)

I-InChi Key:

YQSZJOABXRROQR-UHFFFAOYSA-N

Igama elingukhiye:

3002056-30-3;CAS:3002056-30-3;CAS:3002056-30-3;NST-628;NST628;NST 628

Ukunyibilika: 

Isitoreji:Yomile, emnyama futhi ku-0 -4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

Incazelo:

I-NST-628 iyindlela ye-MAPK yejeli yemolekyuli enezivimbelo zegazi ebuchosheni, engavimbela i-RAF phosphorylation kanye nokusebenza kwe-MEK.

Ithagethi: i-RAF phosphorylation ne-MEK