I-IACS-010759

Igama Lekhemikhali:

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole

Ikhodi ye-SMILES:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC)N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

Ikhodi ye-InChi:

I-InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31 -34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H ,10-13,15H2,1-2H3

I-InChi Key:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Igama elingukhiye:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-IACS-010759 noma i-IACS-10759 iyi-Oxidative Phosphorylation Inhibitor enamandla futhi ekhethayo (IC50).< 10 nM) enomsebenzi ongaba khona we-antineoplastic. I-IACS-010759 ibophezela futhi ivimbele inkimbinkimbi I yochungechunge lwezokuthutha lwe-electron (NADH ubiquinone oxidoreductase), ngaleyo ndlela incisha amangqamuzana esimila izakhi, namandla, futhi ivimbele ukukhiqizwa kwe-nucleotide ne-amino acid, eyenza i-autophagy, ibangele ukufa kweseli lesimila futhi ivimbele iseli. ukwanda. I-Mitochondrial complex I, efakwe ngokweqile kumaseli omdlavuza ukuze ihlangabezane nezidingo zawo ezikhulayo zamandla, idlala indima ebalulekile ekukhuthazeni ukwanda kwamangqamuzana omdlavuza.

Ithagethi: OXPHOS