I-Flibanserin

Igama Lekhemikhali:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

Ikhodi ye-SMILES:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Ikhodi ye-InChi:

I-InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

I-InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Igama elingukhiye:

Flibanserin, 167933-07-5

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-Flibanserin iyi-agonist egcwele ye-5-HT1A receptor (Ki = 1 nM) futhi, enobudlelwane obuphansi, njengomphikisi we-5-HT2A receptor (Ki = 49 nM) kanye nomphikisi noma i-agonist eyingxenye ebuthakathaka kakhulu ye-D4 receptor ( Ki = 4–24 nM). Naphezu kokuhlobana okukhulu kakhulu kwe-flibanserin ye-5-HT1A receptor, futhi ngenxa yezizathu ezingaziwa, i-flibanserin ithatha i-5-HT1A kanye ne-5-HT2A receptors ku-vivo ngamaphesenti afanayo. I-Flibanserin iphinde ibe nokuhambisana okuphansi kwe-5-HT2B receptor (Ki = 89.3 nM) kanye ne-5-HT2C receptor (Ki = 88.3 nM), kokubili eziphatha njengomuntu ophikisana nayo. I-Flibanserin ikhetha ngokukhethekileyo ama-receptors e-5-HT1A ku-prefrontal cortex, ekhombisa ukukhetha kwesifunda, futhi kutholakale ukuthi yandisa amazinga e-dopamine ne-norepinephrine futhi yehlisa amazinga e-serotonin ku-rat prefrontal cortex, izenzo ezanqunywa ukuthi zixhunywe ngokusebenza kwe-5-HT1A. umamukeli.[12] Kanjalo, i-flibanserin iye yachazwa njenge-norepinephrine-dopamine disinhibitor (NDDI). I-Flibanserin yavunywa ngo-Agasti 2015 yokwelashwa kwabesifazane abangaphambi kokuya esikhathini abane-hypoactive sex disorder disorder (HSDD).

Ithagethi: 5HT