I-BAY 61-3606 2HCl
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 1g | Kukhona kusitoki | 1200 |
| 10g | Kukhona kusitoki | 5000 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
2--[[7-(3,4-Dimethoxyphenyl) imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride
Ikhodi ye-SMILES:
O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl
Ikhodi ye-InChi:
I-InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) ;2*1h
I-InChi Key:
SPMFELFGGPQLN-UHFFFAOYSA-N
Igama elingukhiye:
BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)
Incazelo:
I-BAY 61-3606 inamandla (Ki = 7.5 nM) kanye ne-inhibitor ekhethiwe ye-Syk kinase. I-BAY 61-3606 ayizange ivimbele ukuwohloka kwegranulation kuphela (amanani e-IC50 phakathi kuka-5 no-46 nM) kodwa futhi nomlamuleli we-lipid kanye nokuhlanganiswa kwe-cytokine kumaseli e-mast. I-BAY 61-3606 ibisebenza kahle kakhulu kuma-basophil atholwe ezifundweni zabantu ezinempilo (IC50 = 10 nM) futhi ibonakala okungenani inamandla kuma-basophil atholwe ezifundweni ze-atopic (i-serum ephezulu IgE) (IC50 = 8.1 nM). Ukusebenza kwe-B cell receptor kanye nama-receptors wengxenye ye-Fc ye-IgG yokusayina kuma-eosinophils nama-monocyte nawo acindezelwa ngamandla yi-BAY 61-3606.
Ithagethi: Syk
