BI-3406
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 0.5g | Kukhona kusitoki | 850 |
| 1g | Kukhona kusitoki | 1450 |
| 5g | Kukhona kusitoki | 6200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine
Ikhodi ye-SMILES:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2
Ikhodi ye-InChi:
I-InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1
I-InChi Key:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Igama elingukhiye:
BI-3406; BI 3406; BI3406
Ukunyibilika:
Isitoreji:
Incazelo:
I-BI-3406 Inamandla & Ikhethiwe I-SOS1::I-KRAS Inhibitor (IC50=5 nM), Evula Indlela Entsha Yokwelapha Amathumba Aqhutshwa yi-KRAS. I-BI 3406 ibophezela ngokukhetha ku-SOS1 futhi ivimbe ukusebenzisana ne-KRAS, ngokunganaki ukuguqulwa kwe-KRAS. I-BI 3406 ibangela i-RAS GTP nokuncipha kwe-peRK futhi ivimbele ukukhula kwamaseli we-KRAS olayini beseli abashintshile, ethwala iningi lezinguquko ezijwayelekile ze-KRAS (okungukuthi i-G12D, G12V, G13D nezinye). I-BI 3406, lapho inikezwa ngomlomo kumagundane aphethe isimila, ibangela umphumela oncike kumthamo wesimila ongaguqulwa ube ukuhlehla uma kuhlanganiswa ne-MEK1 inhibition.
Ithagethi: SOS1
