I-BMS-986165

Igama Lekhemikhali:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 - i-carboxamide

Ikhodi ye-SMILES:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Ikhodi ye-InChi:

I-InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3

I-InChi Key:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Igama elingukhiye:

1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9;BMS-986165; I-BMS 986165; I-BMS986165; I-Deucravacitinib

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:Eyomile, emnyama futhi ku-0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

Incazelo:

I-BMS-986165 iyi-Highly Potent and Selective Allosteric Inhibitor ye-TYK2. I-BMS-986165 Blocks Il-12, IL-23 kanye nohlobo I-Interferon Signaling futhi Ihlinzeka Ngokusebenza Okuqinile Kumamodeli Angaphambi Komtholampilo Wezifo Zamathumbu Ezivuvukalayo. I-MS-986165 ibophezela ngamandla kusizinda se-Tyk2 pseudokinase (Ki = 0.02 nM), futhi ikhetha kakhulu ngokumelene nephaneli yama-265 kinases nama-pseudokinases. I-compound ivimbele ngokunamandla i-IL-23-, IL-12-, kanye ne-Type I interferon-driven-driven cell signaling and transcriptional responses (IC50 range 2-14 nM).

Ithagethi: TYK2