I-SOS1

IKATI #	Igama Lomkhiqizo	Incazelo
CPD10000	BI-3406	I-BI-3406 Inamandla & Ikhethiwe I-SOS1::I-KRAS Inhibitor (IC50=5 nM), Evula Indlela Entsha Yokwelapha Amathumba Aqhutshwa yi-KRAS. I-BI 3406 ibophezela ngokukhetha ku-SOS1 futhi ivimbe ukusebenzisana ne-KRAS, ngokunganaki ukuguqulwa kwe-KRAS. I-BI 3406 ibangela i-RAS GTP kanye nokuncipha kwe-perK futhi ivimbele ukukhula kwamaseli we-KRAS olayini beseli abashintshile, ethwala iningi lezinguquko ezijwayelekile ze-KRAS (okungukuthi i-G12D, G12V, G13D nezinye). I-BI 3406, lapho inikezwa ngomlomo kumagundane aphethe isimila, idala umphumela oncike kumthamo wesimila ongashintshwa ube ukuhlehla uma kuhlanganiswa ne-MEK1 inhibition.
CPD2807	I-BAY-293	I-BAY-293 iyisivimbeli se-SOS1 esinamandla esivimba ukusebenzisa i-RAS ngokuphazamiseka kokusebenzisana kwe-RAS-SOS1. I-BAY-293) ivimbela ngokukhetha ukusebenzisana kwe-KRAS-SOS1 ne-IC50 yama-21 nM futhi iwuphenyo lwamakhemikhali olubalulekile lophenyo oluzayo.