I-BAY-299

Igama Lekhemikhali:

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H) -dione

Ikhodi ye-SMILES:

OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

Ikhodi ye-InChi:

I-InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7- 16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1- 3h3

I-InChi Key:

OFWWWKUCDUISA-UHFFFAOYSA-N

Igama elingukhiye:

BAY-299, BAY 299, BAY299, 2080306-23-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-BAY-299 iyisivimbeli esinamandla nesikhethayo sephrotheni yomndeni ye-bromodomain kanye ne-PHD eneminwe (BRPF) i-BRD1 (IC50 = 6 nM), eyaziwa nangokuthi i-BRPF2, kanye ne-bromodomain yesibili ye-transcription initiation factor TFIID subunits 1 (TAF1; IC50) = 13 nM).1 I-BAY-299 i > ukukhetha okuphindwe ka-30 kune-BRPF1, BRPF3, BRD9, ne-ATAD2 futhi i>>300 ngokuphindwe ukukhetha kune-BRD4.

Ithagethi: BRPF