I-Verucerfont

Igama Lekhemikhali:

(S)-3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-(1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl)pyrazolo[1, 5-a]pyrimidin-7-amine

Ikhodi ye-SMILES:

CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4

Ikhodi ye-InChi:

I-InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28( 19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1

I-InChi Key:

VKHVAUKFLBBZFJ-SFHVURJKSA-N

Igama elingukhiye:

I-Verucerfont, GSK561679, GSK 561679, GSK-561679, NBI77860, NBI 77860, NBI-77860, 885220-61-1

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

"I-Verucerfont, eyaziwa nangokuthi i-GSK561679 kanye ne-NBI77860, iphikisana ne-CRF-1. I-Verucerfont ivimba isamukeli se-CRH-1, ngakho-ke yehlisa ukukhululwa kwe-ACTH kulandela ukucindezeleka okungapheli. Ingaphansi kophenyo njengendlela yokwelapha engase ibe khona ngenxa yotshwala, njengoba ukucindezeleka okungapheli kuvame ukuvela. isici kukho kokubili ukuthuthukiswa kotshwala kanye nokubuyela ekubuyiseleni izidakwa ezidakayo Kubonise imiphumela ethembisayo ezifundweni zezilwane kodwa akuzange kuhlolwe kubantu.

Ithagethi: CRF-1