I-ARS-1620

I-ARS-1620
  • Igama:I-ARS-1620
  • Inombolo yekhathalogi:Idatha ye-CPDB1588
  • Inombolo ye-CAS:1698055-85-4
  • Isisindo se-Molecular:430.84
  • I-Chemical Formula:I-C21H17ClF2N4O2
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)
    100mg Kukhona kusitoki 800
    500mg Kukhona kusitoki 1500
    1g Kukhona kusitoki 2000
    Osayizi abengeziwe Thola Izingcaphuno Thola Izingcaphuno

    Igama Lekhemikhali:

    (S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-zu-1-one

    Ikhodi ye-SMILES:

    C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl

    Ikhodi ye-InChi:

    I-InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25- 11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2

    I-InChi Key:

    QIQWMIZVWVSRAS-UHFFFAOYSA-N

    Igama elingukhiye:

    ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

    Ukunyibilika:I-Soluble ku-DMSO

    Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

    Incazelo:

    I-ARS-1620 iwumkhiqizo oklanywe kusukela ku-ARS-853, okuyi-S-IIP G12C inhibitor enamandla futhi ekhethiwe. I-ARS-1620 kulindeleke ukuthi ibe isu lokwelapha i-p.G12C KRAS yomdlavuza oguqukayo.

    Ithagethi: KRAS (K-Ras G12C)


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