Trelagliptin

Orukọ Kemikali:

(R) -2- ((6- (3-aminoperidin-1-yl)) -3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -yl) methyl) -4-fluorobenzonitrile succinate.

KỌỌDỌ SMILES:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

Koodu InChi:

InChi=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)1 0-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1 /s1

Bọtini InChi:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

Koko-ọrọ:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

Trelagliptin, ti a tun mọ ni SYR-472, jẹ inhibitor dipeptidyl peptidase-4 (DPP-4) ti n ṣiṣẹ pipẹ ti Takeda ni idagbasoke fun itọju iru àtọgbẹ 2 (T2D). Itọju SYR-472 lẹẹkan-ọsẹ ṣe iṣelọpọ ile-iwosan ati awọn ilọsiwaju pataki iṣiro ni iṣakoso glycemic ni awọn alaisan ti o ni àtọgbẹ iru 2. O farada daradara ati pe o le jẹ aṣayan itọju titun fun awọn alaisan ti o ni arun yii. Trelagliptin (Zafatek (®)) ti fọwọsi ni ilu Japan fun itọju iru 2 diabetes mellitus (T2DM).

Àfojúsùn: DPP-4