Sitagliptin

Orukọ Kemikali:

Sitagliptin (INN; ti a mọ tẹlẹ bi MK-0431 ati ti o ta labẹ orukọ iṣowo Januvia) jẹ oogun antihyperglycemic ti ẹnu (oògùn dayabetik) ti kilasi inhibitor dipeptidyl peptidase-4 (DPP-4).

KỌỌDỌ SMILES:

O=C(N1CC2=NN=C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]

Koodu InChi:

InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13 (7-26)24-25-15 (27)16 (20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;( H3,1,2,3,4);1H2/t9-;;/m1../s1

Bọtini InChi:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Koko-ọrọ:

Sitagliptin, Sitagliptin fosifeti, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

Sitagliptin (INN; ti a mọ tẹlẹ bi MK-0431 ati ti o ta labẹ orukọ iṣowo Januvia) jẹ oogun antihyperglycemic ti ẹnu (oògùn dayabetik) ti kilasi inhibitor dipeptidyl peptidase-4 (DPP-4). O ti ni idagbasoke ati tita nipasẹ Merck & Co. Oogun ti n ṣe idiwọ enzymu yii jẹ lilo boya nikan tabi ni idapo pẹlu awọn oogun antihyperglycemic miiran ti ẹnu (gẹgẹbi metformin tabi thiazolidinedione) fun itọju ti àtọgbẹ mellitus iru 2. Anfaani oogun yii jẹ Awọn ipa ẹgbẹ kekere rẹ (fun apẹẹrẹ, hypoglycemia ti o dinku, ere iwuwo ti o dinku) ni iṣakoso awọn iye glukosi ẹjẹ. Exenatide (Byetta) tun ṣiṣẹ nipasẹ ipa rẹ lori eto incretin.

Àfojúsùn: DPP-4