TAS-120

Orukọ Kemikali:

1- [(3S) -3- [4-amino-3-[2- (3,5-dimethoxyphenyl) ethynyl] -1H-pyrazolo [3,4-d] pyrimidin-1-yl] -1-pyrrolidinyl -2-propen-1-ọkan

KỌỌDỌ SMILES:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Koodu InChi:

InChi=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5 -14-9-16 (30-2) 11-17 (10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23, 24,25) / t15- / m0 / s1

Bọtini InChi:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Koko-ọrọ:

TAS-120

Solubility: 

Ibi ipamọ: 

Apejuwe:

TAS-120 jẹ inhibitor bioavailable ẹnu ti olugba idagba ifosiwewe fibroblast (FGFR) pẹlu iṣẹ ṣiṣe antineoplastic ti o pọju. FGFR inhibitor TAS-120 ni yiyan ati aibikita ni asopọ si ati dojuti FGFR, eyiti o le ja si idinamọ mejeeji ọna transduction ti o ni ilaja FGFR ati afikun sẹẹli tumo, ati pe iku sẹẹli pọ si ni FGFR-overexpressing awọn sẹẹli tumo. FGFR jẹ olugba tyrosine kinase ti o ṣe pataki si itọsi sẹẹli tumo, iyatọ ati iwalaaye ati ikosile rẹ ti ni atunṣe ni ọpọlọpọ awọn iru sẹẹli tumo.

afojusun: FGFR